The marathon party will open its doors at 4:PM and run all-night long and then some through to 12:PM the following day, spanning across four rooms.
DJs set to play include Jamie Jones, The Blessed Madonna, Adam Beyer, Alfredo, Young Marco, Jayda G, Deborah de Luca, Marco Faraone, Cuartero, Mar-T & Caal, Sidney Charles & Seb Zito and many more.
One of the rooms is a brand new space called 3rd DIMENSION, while the beloved Terraza and Club room will also be open.
Ibiza is set to welcome tourists from June, with the Balearic tourism minister recently saying she is "very optimistic" Brits wil be allowed to the White Isle next month.
Last month it was revealed that Ibiza will not require travellers to take a coronavirus test or quarantine upon arrival this summer.
Tickets for Amnesia’s closing party are on sale now, priced from £33.87. They’re guaranteed to be fully refunded in the event of any pandemic-related cancellation or postponement.
Get tickets here.
Patrick Hinton is Mixmag's Digital Editor, follow him on Twitter