For Dr Dre, Snoop Dogg and Kendrick Lamar, the performance will also represent a homecoming for the Los Angeles artists.
The group have a combined 43 Grammys and have created 22 Billboard No.1 albums.
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"The opportunity to perform at the Super Bowl Halftime Show, and to do it in my own backyard, will be one of the biggest thrills of my career," Dr Dre said in a statement. "I'm grateful to JAY-Z, Roc Nation, the NFL, and Pepsi as well as Snoop Dogg, Eminem, Mary J. Blige and Kendrick Lamar for joining me in what will be an unforgettable cultural moment."
Shawn "JAY-Z" Carter, rapper and founder of Roc Nation, said in a statement; "On February 13, 2022, at the Super Bowl LVI in Inglewood, California, in the new SoFi Stadium, Dr Dre, a musical visionary from Compton, Snoop Dogg, an icon from Long Beach and Kendrick Lamar, a young musical pioneer in his own right, also from Compton, will take center field for a performance of a lifetime."
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"They will be joined by the lyrical genius, Eminem, and the timeless Queen, Mary J. Blige. This is the Pepsi Super Bowl Halftime Show. This is history in the making."
This is the first Super Bowl to be taking place in California this century.
Aneesa Ahmed is Mixmag's Digital Intern, follow her on Twitter